InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFYA

Summary

InnateDB Gene

IDBG-86491.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFYA

Gene Name

nuclear transcription factor Y, alpha

Synonyms

CBF-A; CBF-B; HAP2; NF-YA

Species

Homo sapiens

Ensembl Gene

ENSG00000001167

Encoded Proteins

IDBP-86493

nuclear transcription factor Y, alpha

IDBP-86495

nuclear transcription factor Y, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:41072945-41099976

Strand

Forward strand

Band

p21.1

Transcripts

ENST00000341376	ENSP00000345702
ENST00000353205	ENSP00000229418

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	39 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0001221	transcription cofactor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000036	regulation of stem cell maintenance
GO:2000648	positive regulation of stem cell proliferation