Version 5.4
Homo sapiens Gene: RAP2C
Summary
InnateDB Gene IDBG-86513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAP2C
Gene Name RAP2C, member of RAS oncogene family
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000123728
Encoded Proteins
IDBP-86515
RAP2C, member of RAS oncogene family
IDBP-86517
RAP2C, member of RAS oncogene family
IDBP-812233
RAP2C, member of RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:132203024-132219480
Strand Reverse strand
Band q26.2
Transcripts
ENST00000342983 ENSP00000340274
ENST00000370874 ENSP00000359911
ENST00000460462
ENST00000490400
ENST00000620646 ENSP00000484870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0030336 negative regulation of cell migration
GO:0031954 positive regulation of protein autophosphorylation
GO:0032486 Rap protein signal transduction
GO:0061097 regulation of protein tyrosine kinase activity
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050029
View Gene Order
ENSBTAG00000004131
Not yet available
Cross-References
SwissProt Q9Y3L5
TrEMBL
UniProt Splice Variant
Entrez Gene 57826
UniGene Hs.119889 Hs.607127 Hs.730583
RefSeq NM_001271186 NM_001271187 NM_021183 XM_006724775
HUGO HGNC:21165
OMIM
CCDS CCDS14632 CCDS76024
HPRD
IMGT
EMBL AK124801 AL049685 AY298955 BC003403 CH471107 Z78022
GenPept AAH03403 AAP55684 BAG54098 CAB41256 CAI42719 EAX11782
RNA Seq Atlas 57826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca