Version 5.4
Homo sapiens Gene: ARHGEF16
Summary
InnateDB Gene IDBG-86592.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF16
Gene Name Rho guanine nucleotide exchange factor (GEF) 16
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130762
Encoded Proteins
IDBP-86594
Rho guanine nucleotide exchange factor (GEF) 16
IDBP-86598
Rho guanine nucleotide exchange factor (GEF) 16
IDBP-86600
Rho guanine nucleotide exchange factor (GEF) 16
IDBP-363814
Rho guanine nucleotide exchange factor (GEF) 16
IDBP-363816
Rho guanine nucleotide exchange factor (GEF) 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:3454426-3481113
Strand Forward strand
Band p36.32
Transcripts
ENST00000378378 ENSP00000367629
ENST00000378373 ENSP00000367624
ENST00000378371 ENSP00000367622
ENST00000445297 ENSP00000411936
ENST00000418137 ENSP00000390853
ENST00000464620
ENST00000485984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
GO:0030165 PDZ domain binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0032863 activation of Rac GTPase activity
GO:0032864 activation of Cdc42 GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0060326 cell chemotaxis
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029032
View Gene Order
ENSBTAG00000020837
Not yet available
Pathways
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.87435
RefSeq NM_014448 XM_005244740 XM_006710578
HUGO
OMIM
CCDS CCDS46
HPRD 12478
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca