Version 5.4
Homo sapiens Gene: TREML4
Summary
InnateDB Gene IDBG-86619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREML4
Gene Name triggering receptor expressed on myeloid cells-like 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188056
Encoded Proteins
IDBP-86621
triggering receptor expressed on myeloid cells-like 4
IDBP-481882
triggering receptor expressed on myeloid cells-like 4
IDBP-475618
triggering receptor expressed on myeloid cells-like 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25848864
[Mus musculus] Treml4 is an essential positive regulator of Tlr7 signalling. Treml4(-/-) macrophages are hyporesponsive to Tlr7 agonists and fail to produce type I interferons due to impaired phosphorylation of Stat1 by Mapk14 and decreased recruitment of Myd88 to Tlr7.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41228324-41238882
Strand Forward strand
Band p21.1
Transcripts
ENST00000341495 ENSP00000342570
ENST00000448827 ENSP00000418078
ENST00000461240 ENSP00000418480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000051682
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 285852
UniGene Hs.434181
RefSeq NM_198153 XM_005249025
HUGO HGNC:30807
OMIM 614664
CCDS CCDS34446
HPRD 15548
IMGT
EMBL
GenPept
RNA Seq Atlas 285852

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca