InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AK1

Summary

InnateDB Gene

IDBG-86687.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK1

Gene Name

adenylate kinase 1

Synonyms

HTL-S-58j

Species

Homo sapiens

Ensembl Gene

ENSG00000106992

Encoded Proteins

IDBP-86689

adenylate kinase 1

IDBP-86693

adenylate kinase 1

IDBP-86695

adenylate kinase 1

IDBP-381135

adenylate kinase 1

IDBP-593930

adenylate kinase 1

IDBP-602633

adenylate kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:127866480-127877743

Strand

Reverse strand

Band

q34.11

Transcripts

ENST00000373176	ENSP00000362271
ENST00000223836	ENSP00000223836
ENST00000373156	ENSP00000362249
ENST00000413016	ENSP00000392314
ENST00000550143	ENSP00000449130
ENST00000550992	ENSP00000448741

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0019205	nucleobase-containing compound kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006172	ADP biosynthetic process
GO:0007050	cell cycle arrest
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0016310	phosphorylation
GO:0044281	small molecule metabolic process
GO:0046033	AMP metabolic process
GO:0046034	ATP metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0001520	outer dense fiber
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0036126	sperm flagellum
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026817

View Gene Order

ENSBTAG00000006305

Not yet available

Pathways

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.175473

RefSeq

NM_000476

HUGO

OMIM

CCDS

CCDS6881

HPRD

00046

IMGT

EMBL

GenPept

RNA Seq Atlas