Version 5.4
Homo sapiens Gene: MDFI
Summary
InnateDB Gene IDBG-86745.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MDFI
Gene Name MyoD family inhibitor
Synonyms I-MF; I-mfa
Species Homo sapiens
Ensembl Gene ENSG00000112559
Encoded Proteins
IDBP-86747
MyoD family inhibitor
IDBP-86749
MyoD family inhibitor
IDBP-86751
MyoD family inhibitor
IDBP-378295
MyoD family inhibitor
IDBP-378297
MyoD family inhibitor
IDBP-378301
MyoD family inhibitor
IDBP-378309
MyoD family inhibitor
IDBP-378310
MyoD family inhibitor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41636882-41654246
Strand Forward strand
Band p21.1
Transcripts
ENST00000373051 ENSP00000362142
ENST00000373050 ENSP00000362141
ENST00000230321 ENSP00000230321
ENST00000432027 ENSP00000413226
ENST00000419164 ENSP00000393881
ENST00000441667 ENSP00000406600
ENST00000446650 ENSP00000411829
ENST00000435476 ENSP00000403587
ENST00000471092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 165 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 165 [view]
Protein-Protein 163 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007257 activation of JUN kinase activity
GO:0009790 embryo development
GO:0009950 dorsal/ventral axis specification
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043392 negative regulation of DNA binding
GO:0048704 embryonic skeletal system morphogenesis
GO:0060707 trophoblast giant cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032717
View Gene Order
ENSBTAG00000019343
Not yet available
Cross-References
SwissProt
TrEMBL B1AKC0 B1AKC1
UniProt Splice Variant
Entrez Gene 4188
UniGene Hs.520119
RefSeq NM_001300805 NM_005586 XM_005249117 XM_005249118 XM_005249119
HUGO HGNC:6967
OMIM 604971
CCDS CCDS4857 CCDS75451
HPRD 07280
IMGT
EMBL AL035588
GenPept
RNA Seq Atlas 4188

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca