Homo sapiens Gene: CCND3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-86973.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CCND3 | ||||||||||||||||||||||
Gene Name | cyclin D3 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000112576 | ||||||||||||||||||||||
Encoded Proteins |
cyclin D3
cyclin D3
cyclin D3
cyclin D3
cyclin D3
cyclin D3
cyclin D3
cyclin D3
cyclin D3
cyclin D3
cyclin D3
cyclin D3
cyclin D3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 6:41934933-42050357 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | p21.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
BCR pathway
TSH pathway
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REACTOME |
Cyclin D associated events in G1 pathway
Transcriptional regulation of white adipocyte differentiation pathway
G1 Phase pathway
Developmental Biology pathway
Mitotic G1-G1/S phases pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
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KEGG |
Wnt signaling pathway pathway
Cell cycle pathway
Focal adhesion pathway
Jak-STAT signaling pathway pathway
p53 signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Coregulation of Androgen receptor activity
E2F transcription factor network
IL2 signaling events mediated by STAT5
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Cross-References | |||||||||||||||||||||||
SwissProt | P30281 | ||||||||||||||||||||||
TrEMBL | D6RDL3 D6RIX2 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 896 | ||||||||||||||||||||||
UniGene | Hs.597485 | ||||||||||||||||||||||
RefSeq | NM_001136017 NM_001136125 NM_001136126 NM_001287427 NM_001287434 NM_001760 | ||||||||||||||||||||||
HUGO | HGNC:1585 | ||||||||||||||||||||||
OMIM | 123834 | ||||||||||||||||||||||
CCDS | CCDS47426 CCDS47425 CCDS47427 CCDS4863 CCDS75452 | ||||||||||||||||||||||
HPRD | 00452 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF517525 AK057206 AK097856 AK315421 AL160163 AL513008 BC011616 BX400719 CH471081 CR542246 M88084 M88085 M88086 M88087 M90814 M92287 | ||||||||||||||||||||||
GenPept | AAA51927 AAA51929 AAA52137 AAH11616 AAM51826 BAG37810 BAG51884 CAG47042 CAI23491 EAX04071 | ||||||||||||||||||||||
RNA Seq Atlas | 896 | ||||||||||||||||||||||