Version 5.4
Homo sapiens Gene: LBX1
Summary
InnateDB Gene IDBG-87067.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LBX1
Gene Name ladybird homeobox 1
Synonyms homeobox; HPX-6; HPX6; LBX1H
Species Homo sapiens
Ensembl Gene ENSG00000138136
Encoded Proteins
IDBP-87069
ladybird homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:101226195-101229794
Strand Reverse strand
Band q24.32
Transcripts
ENST00000370193 ENSP00000359212
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0001947 heart looping
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007517 muscle organ development
GO:0008285 negative regulation of cell proliferation
GO:0009653 anatomical structure morphogenesis
GO:0021522 spinal cord motor neuron differentiation
GO:0021920 regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
GO:0045665 negative regulation of neuron differentiation
GO:0048663 neuron fate commitment
GO:0048664 neuron fate determination
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025216
View Gene Order
ENSBTAG00000002261
Not yet available
Cross-References
SwissProt P52954
TrEMBL Q6LBH2
UniProt Splice Variant
Entrez Gene 10660
UniGene Hs.37128
RefSeq NM_006562 XM_005269443
HUGO HGNC:16960
OMIM 604255
CCDS CCDS31270
HPRD
IMGT
EMBL AL135794 BC069156 BC136321 CH471066 X74863 X90828
GenPept AAH69156 AAI36322 CAA52856 CAA62342 CAH72508 EAW49777
RNA Seq Atlas 10660

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca