Homo sapiens Gene: PTCRA
Summary
InnateDB Gene IDBG-87386.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol PTCRA
Gene Name pre T-cell antigen receptor alpha
Synonyms PT-ALPHA; PTA;
Species Homo sapiens
Ensembl Gene ENSG00000171611
Encoded Proteins
pre T-cell antigen receptor alpha
pre T-cell antigen receptor alpha
pre T-cell antigen receptor alpha
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42883727-42893573
Strand Forward strand
Band p21.1
Transcripts
ENST00000304672 ENSP00000304447
ENST00000446507 ENSP00000392288
ENST00000441198 ENSP00000409550
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0070244 negative regulation of thymocyte apoptotic process
Cellular Component
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Notch signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
C-MYB transcription factor network
Notch signaling pathway
Cross-References
SwissProt Q6ISU1
TrEMBL
UniProt Splice Variant
Entrez Gene 171558
UniGene
RefSeq NM_001243169 NM_001243170 NM_138296
HUGO 21290
OMIM 606817
CCDS CCDS4874
HPRD 08435
IMGT
EMBL AF084941 AF101436 AF165312 AL035587 BC069336 BC100771 BC100772 BC100773 BC100774 BC153829 U36759 U38996
GenPept AAB06194 AAB18373 AAC83346 AAF21890 AAF89556 AAH69336 AAI00772 AAI00773 AAI00774 AAI00775 AAI53830 CAI21484
ImmGen PTCRA (murine)
RNA Seq Atlas 171558