Homo sapiens Gene: PTCRA

Summary
InnateDB Gene IDBG-87386.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol PTCRA
Gene Name pre T-cell antigen receptor alpha
Synonyms PT-ALPHA; PTA
Species Homo sapiens
Ensembl Gene ENSG00000171611
Encoded Proteins
IDBP-87388 pre T-cell antigen receptor alpha
IDBP-379005 pre T-cell antigen receptor alpha
IDBP-379007 pre T-cell antigen receptor alpha
Entrez Gene
Summary The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6: 42883727-42893573
Strand Forward strand
Band p21.1
Transcripts
ENST00000304672  ENSP00000304447
ENST00000446507  ENSP00000392288
ENST00000441198  ENSP00000409550
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein‑Protein  4
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0070244 negative regulation of thymocyte apoptotic process
Cellular Component
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000036858 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000017097 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa04330  Notch signaling pathway
INOH
PID BIOCARTA
PID NCI
cmyb_pathway C-MYB transcription factor network
notch_pathway Notch signaling pathway
Cross-References
SwissProt Q6ISU1 
TrEMBL
UniProt Splice Variant
Entrez Gene 171558 
UniGene
RefSeq NM_001243169  NM_001243170  NM_138296 
HUGO 21290 
OMIM 606817
CCDS CCDS4874 
HPRD 08435
IMGT
EMBL AF084941 AF101436 AF165312 AL035587 BC069336 BC100771 BC100772 BC100773 BC100774 BC153829 U36759 U38996
GenPept AAB06194  AAB18373  AAC83346  AAF21890  AAF89556  AAH69336  AAI00772  AAI00773  AAI00774  AAI00775  AAI53830  CAI21484 
ImmGen PTCRA (murine) 
RNA Seq Atlas 171558