Version 5.4
Homo sapiens Gene: DNAJC5
Summary
InnateDB Gene IDBG-87436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJC5
Gene Name DnaJ (Hsp40) homolog, subfamily C, member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101152
Encoded Proteins
IDBP-87442
DnaJ (Hsp40) homolog, subfamily C, member 5
IDBP-593483
DnaJ (Hsp40) homolog, subfamily C, member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:63895182-63936031
Strand Forward strand
Band q13.33
Transcripts
ENST00000360864 ENSP00000354111
ENST00000470551 ENSP00000434744
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0043008 ATP-dependent protein binding
Biological Process
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0008219 cell death
GO:0043524 negative regulation of neuron apoptotic process
Cellular Component
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0042470 melanosome
GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000826
View Gene Order
ENSBTAG00000015796
Not yet available
Pathways
NETPATH
REACTOME
REACT_23947
GABA synthesis, release, reuptake and degradation pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.164419 Hs.608607 Hs.707118
RefSeq NM_025219
HUGO
OMIM
CCDS CCDS13546
HPRD 08539
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca