Version 5.4
Homo sapiens Gene: ARL4A
Summary
InnateDB Gene IDBG-8759.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL4A
Gene Name ADP-ribosylation factor-like 4A
Synonyms ARL4
Species Homo sapiens
Ensembl Gene ENSG00000122644
Encoded Proteins
IDBP-8761
ADP-ribosylation factor-like 4A
IDBP-237027
ADP-ribosylation factor-like 4A
IDBP-237029
ADP-ribosylation factor-like 4A
IDBP-237031
ADP-ribosylation factor-like 4A
IDBP-292815
ADP-ribosylation factor-like 4A
IDBP-365379
ADP-ribosylation factor-like 4A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:12686856-12690934
Strand Forward strand
Band p21.3
Transcripts
ENST00000356797 ENSP00000349250
ENST00000396664 ENSP00000379899
ENST00000396663 ENSP00000379898
ENST00000396662 ENSP00000379897
ENST00000404894 ENSP00000385236
ENST00000439721 ENSP00000397651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047446
View Gene Order
ENSBTAG00000002869
Not yet available
Cross-References
SwissProt P40617
TrEMBL A0A024R9Z2 C9J7Q9
UniProt Splice Variant
Entrez Gene 10124
UniGene Hs.245540 Hs.603315 Hs.741524
RefSeq NM_212460 NM_001037164 NM_001195396 NM_005738
HUGO HGNC:695
OMIM 604786
CCDS CCDS5359
HPRD 11987
IMGT
EMBL AC011891 AF493890 AK313233 BC001111 BC003027 CH236948 CH471073 U73960
GenPept AAB39713 AAH01111 AAH03027 AAM12604 BAG36044 EAL24295 EAW93650 EAW93652
RNA Seq Atlas 10124

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca