InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CUL7

Summary

InnateDB Gene

IDBG-87630.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUL7

Gene Name

cullin 7

Synonyms

3M1; dJ20C7.5; KIAA0076

Species

Homo sapiens

Ensembl Gene

ENSG00000044090

Encoded Proteins

IDBP-87632

cullin 7

IDBP-599993

cullin 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:43037617-43053945

Strand

Reverse strand

Band

p21.1

Transcripts

ENST00000265348	ENSP00000265348
ENST00000478630
ENST00000535468	ENSP00000438788

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000281	mitotic cytokinesis
GO:0001570	vasculogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0001890	placenta development
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007030	Golgi organization
GO:0007088	regulation of mitosis
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0050775	positive regulation of dendrite morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005680	anaphase-promoting complex
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0031467	Cul7-RING ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm
GO:1990393	3M complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038545

View Gene Order

ENSBTAG00000012749

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_18273

XBP1(S) activates chaperone genes pathway

REACT_18368

IRE1alpha activates chaperones pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

Q14999

TrEMBL

UniProt Splice Variant

Entrez Gene

9820

UniGene

Hs.520136

RefSeq

NM_001168370 XM_006715285 NM_014780 XM_005249503

HUGO

HGNC:21024

OMIM

609577

CCDS

CCDS55003 CCDS4881

HPRD

09901

IMGT

EMBL

AK302668 AL136304 AL355385 BC033647 D38548

GenPept

AAH33647 BAA07551 BAG63902 CAI13779 CAI19793

RNA Seq Atlas

9820