InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRPF6

Summary

InnateDB Gene

IDBG-87633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRPF6

Gene Name

PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)

Synonyms

ANT-1; ANT1; C20orf14; hPrp6; Prp6; RP60; SNRNP102; TOM; U5-102K

Species

Homo sapiens

Ensembl Gene

ENSG00000101161

Encoded Proteins

IDBP-87635

PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:63981135-64033100

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000266079

ENSP00000266079

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	99 [view]
Protein-Protein	97 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding
GO:0044822	poly(A) RNA binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000244	spliceosomal tri-snRNP complex assembly
GO:0000245	spliceosomal complex assembly
GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0006403	RNA localization
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005682	U5 snRNP
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0046540	U4/U6 x U5 tri-snRNP complex
GO:0071001	U4/U6 snRNP
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002455

View Gene Order

ENSBTAG00000011656

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_1753

mRNA Splicing - Minor Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

O94906

TrEMBL

UniProt Splice Variant

Entrez Gene

24148

UniGene

Hs.31334

RefSeq

NM_012469

HUGO

HGNC:15860

OMIM

613979

CCDS

CCDS13550

HPRD

IMGT

EMBL

AB019219 AF026031 AF221842 AK001554 AK314310 AL118506 AL137320 AL355803 AL356790 BC001666

GenPept

AAD01798 AAF66128 AAH01666 BAA37140 BAG36962 BAG50938 CAB70695 CAC16610 CAH71582 CAI21906

RNA Seq Atlas

24148