Homo sapiens Gene: MRPL2
Summary
InnateDB Gene IDBG-87639.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL2
Gene Name mitochondrial ribosomal protein L2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112651
Encoded Proteins
mitochondrial ribosomal protein L2
mitochondrial ribosomal protein L2
mitochondrial ribosomal protein L2
mitochondrial ribosomal protein L2
mitochondrial ribosomal protein L2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:43054029-43059806
Strand Reverse strand
Band p21.1
Transcripts
ENST00000230413 ENSP00000230413
ENST00000388752 ENSP00000373404
ENST00000485654
ENST00000489623 ENSP00000419753
ENST00000470667
ENST00000491898
ENST00000480286
ENST00000487429 ENSP00000417101
ENST00000468957 ENSP00000419710
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.55041
RefSeq NM_001300848 NM_015950 XM_005249162
HUGO
OMIM
CCDS CCDS34454 CCDS75458
HPRD 14745
IMGT
EMBL
GenPept
RNA Seq Atlas