InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLEKHG5

Summary

InnateDB Gene

IDBG-87695.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEKHG5

Gene Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000171680

Encoded Proteins

IDBP-87717

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-87719

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-87723

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-87725

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-87727

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-87729

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-227099

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-227103

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-598997

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

IDBP-596219

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:6466092-6520061

Strand

Reverse strand

Band

p36.31

Transcripts

ENST00000377748	ENSP00000366977
ENST00000377740	ENSP00000366969
ENST00000377732	ENSP00000366961
ENST00000377728	ENSP00000366957
ENST00000377725	ENSP00000366954
ENST00000340850	ENSP00000344570
ENST00000400915	ENSP00000383706
ENST00000400913	ENSP00000383704
ENST00000489097
ENST00000487949
ENST00000537245	ENSP00000439625
ENST00000535355	ENSP00000441445

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035767	endothelial cell chemotaxis
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043542	endothelial cell migration
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0030027	lamellipodium
GO:0030139	endocytic vesicle
GO:0048471	perinuclear region of cytoplasm