Version 5.4
Homo sapiens Gene: PPRC1
Summary
InnateDB Gene IDBG-87791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPRC1
Gene Name peroxisome proliferator-activated receptor gamma, coactivator-related 1
Synonyms PRC
Species Homo sapiens
Ensembl Gene ENSG00000148840
Encoded Proteins
IDBP-87793
peroxisome proliferator-activated receptor gamma, coactivator-related 1
IDBP-87795
peroxisome proliferator-activated receptor gamma, coactivator-related 1
IDBP-384841
peroxisome proliferator-activated receptor gamma, coactivator-related 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:102132994-102150331
Strand Forward strand
Band q24.32
Transcripts
ENST00000278070 ENSP00000278070
ENST00000370012 ENSP00000359029
ENST00000413464 ENSP00000399743
ENST00000489648
ENST00000462933
ENST00000495914
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055491
View Gene Order
ENSBTAG00000007427
Not yet available
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q5VV67
TrEMBL X6R7H2
UniProt Splice Variant
Entrez Gene 23082
UniGene Hs.533551
RefSeq NM_001288728 NM_015062 XM_006717731 NM_001288727 XM_005269658
HUGO HGNC:30025
OMIM
CCDS CCDS7529 CCDS73186
HPRD 15173
IMGT
EMBL AB011167 AF325193 AL500527 BC002561 BC063806 BC063829
GenPept AAH02561 AAH63806 AAH63829 AAK11573 BAA25521 CAH72218 CAH72219
RNA Seq Atlas 23082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca