InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFKB2

Summary

InnateDB Gene

IDBG-87893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFKB2

Gene Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Synonyms

CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100; p52

Species

Homo sapiens

Ensembl Gene

ENSG00000077150

Encoded Proteins

IDBP-87897

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

IDBP-87899

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

IDBP-384889

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

IDBP-749018

IDBP-749106

IDBP-807168

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 7925301

NFKB2 (p49/p100 subunit) associates efficiently with RELB and up-regulates the synthesis of NFKBIA (IKappaB-alpha).

PMID 18025196

NFKB2 plays a key role in the regulation of RELA activation, suggesting an overlap in the function of NF-kappaB members in canonical and non-canonical pathway signalling.

PMID 18377428

NFKB2 rearrangement gene product (p58) localizes in the nucleus to form a complex with RELA or RELB, suggesting that such NFKB2 gene rearrangement may therefore be a factor in the constitutive activation of NF-kappaB in adult T-cell leukemia (ATL), and thereby playing a role in the ATL pathogenesis.

PMID 17548614

NFKB2 negatively regulates TCR signaling by binding with RELA, RELB, REL and NFKB1 (p50) in the cytoplasm and inhibiting these proteins from entering nucleus.

PMID 19770515

NFKB2 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.

InnateDB Annotation from Orthologs

Summary

PMID 26026270

[Mus musculus] Bacterial cell wall glucosaminyl-muramyl dipeptides (GMDPs) bind to the transcription factor Ybx1 to upregulate Nfkb2 and Cxcr4 gene expression.

Entrez Gene

Summary

This gene encodes one of the subunits of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB transcription factor complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The NFkB complex can consist of different subunits that form both homo- or heterodimers which bind specific kappa-B elements in target genes. This gene encodes the p100 subunit that is processed into the active p52 subunit. This protein can function as both a transcriptional activator and repressor, depending on its dimer partner. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, May 2012]
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:102394110-102402529

Strand

Forward strand

Band

q24.32

Transcripts

ENST00000336486
ENST00000369966	ENSP00000358983
ENST00000189444	ENSP00000189444
ENST00000428099	ENSP00000410256
ENST00000471698	ENSP00000471586
ENST00000467116
ENST00000473400
ENST00000601386	ENSP00000470826
ENST00000593908
ENST00000610498	ENSP00000480211

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	123 [view]
Protein-Protein	89 [view]
Protein-DNA	33 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002268	follicular dendritic cell differentiation
GO:0002467	germinal center formation
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0030198	extracellular matrix organization
GO:0032481	positive regulation of type I interferon production
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038061	NIK/NF-kappaB signaling
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0048536	spleen development
GO:0051092	positive regulation of NF-kappaB transcription factor activity