Version 5.4
Homo sapiens Gene: KLHL21
Summary
InnateDB Gene IDBG-88014.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL21
Gene Name kelch-like 21 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162413
Encoded Proteins
IDBP-88016
kelch-like 21 (Drosophila)
IDBP-88018
kelch-like 21 (Drosophila)
IDBP-722302
IDBP-722573
IDBP-721704
IDBP-812952
kelch-like family member 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:6590724-6614607
Strand Reverse strand
Band p36.31
Transcripts
ENST00000377663 ENSP00000366891
ENST00000377658 ENSP00000366886
ENST00000467612 ENSP00000466089
ENST00000496707 ENSP00000468710
ENST00000463043 ENSP00000466479
ENST00000610898 ENSP00000480631
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0016567 protein ubiquitination
GO:0032465 regulation of cytokinesis
GO:0035853 chromosome passenger complex localization to spindle midzone
Cellular Component
GO:0005737 cytoplasm
GO:0005827 polar microtubule
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073700
View Gene Order
ENSBTAG00000008350
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7EMF2
UniProt Splice Variant
Entrez Gene 9903
UniGene Hs.603155 Hs.7764
RefSeq NM_014851
HUGO HGNC:29041
OMIM
CCDS CCDS30575
HPRD 17239
IMGT
EMBL AL031447 AL591866
GenPept
RNA Seq Atlas 9903

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca