InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL17RA

Summary

InnateDB Gene

IDBG-885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL17RA

Gene Name

interleukin 17 receptor A

Synonyms

CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R

Species

Homo sapiens

Ensembl Gene

ENSG00000177663

Encoded Proteins

IDBP-887

interleukin 17 receptor A

IDBP-810276

interleukin 17 receptor A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. [provided by RefSeq, Jul 2008]
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:17084954-17115694

Strand

Forward strand

Band

q11.1

Transcripts

ENST00000319363	ENSP00000320936
ENST00000477874
ENST00000459971
ENST00000612619	ENSP00000479970

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030368	interleukin-17 receptor activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0032747	positive regulation of interleukin-23 production
GO:0071345	cellular response to cytokine stimulus
GO:0072537	fibroblast activation
GO:1900017	positive regulation of cytokine production involved in inflammatory response

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002897

View Gene Order

ENSBTAG00000011067

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.48353

RefSeq

NM_001289905 NM_014339

HUGO

OMIM

CCDS

CCDS13739

HPRD

10399

IMGT

EMBL

GenPept

RNA Seq Atlas