Version 5.4
Homo sapiens Gene: HMGB3
Summary
InnateDB Gene IDBG-88858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGB3
Gene Name high mobility group box 3
Synonyms HMG-2a; HMG-4; HMG2A; HMG4
Species Homo sapiens
Ensembl Gene ENSG00000029993
Encoded Proteins
IDBP-88860
high mobility group box 3
IDBP-588554
high mobility group box 3
IDBP-382392
high mobility group box 3
IDBP-382398
high mobility group box 3
IDBP-382403
high mobility group box 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19890330
HMGB3 functions as a universal sentinel for nucleic-acid-mediated innate immune responses.
Entrez Gene
Summary HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997 [PubMed 9370291]; Nemeth et al., 2006 [PubMed 16945912]).[supplied by OMIM, Mar 2008]
This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome X:150980509-150990775
Strand Forward strand
Band q28
Transcripts
ENST00000325307 ENSP00000359393
ENST00000448905 ENSP00000442758
ENST00000419110 ENSP00000410354
ENST00000455596 ENSP00000405601
ENST00000430118 ENSP00000417027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0008301 DNA binding, bending
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006310 DNA recombination
GO:0007275 multicellular organismal development
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015217
View Gene Order
ENSBTAG00000005150
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.19114 Hs.591080 Hs.595140
RefSeq NM_001301228 NM_001301229 NM_001301231 NM_005342 XM_005274665
HUGO
OMIM
CCDS CCDS35428
HPRD 02181
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca