Version 5.4
Homo sapiens Gene: DOLPP1
Summary
InnateDB Gene IDBG-88961.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOLPP1
Gene Name dolichyl pyrophosphate phosphatase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167130
Encoded Proteins
IDBP-88963
dolichyl pyrophosphate phosphatase 1
IDBP-88965
dolichyl pyrophosphate phosphatase 1
IDBP-294484
dolichyl pyrophosphate phosphatase 1
IDBP-382088
dolichyl pyrophosphate phosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:129081100-129090438
Strand Forward strand
Band q34.11
Transcripts
ENST00000372546 ENSP00000361625
ENST00000327812 ENSP00000333294
ENST00000406974 ENSP00000384043
ENST00000412363 ENSP00000403278
ENST00000480255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0047874 dolichyldiphosphatase activity
Biological Process
GO:0006487 protein N-linked glycosylation
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0006489 dolichyl diphosphate biosynthetic process
GO:0008610 lipid biosynthetic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026856
View Gene Order
ENSBTAG00000017922
Not yet available
Pathways
NETPATH
REACTOME
REACT_22230
Synthesis of Dolichyl-phosphate pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q86YN1
TrEMBL Q8IUV4
UniProt Splice Variant
Entrez Gene 57171
UniGene Hs.21701
RefSeq NM_001135917 NM_020438
HUGO HGNC:29565
OMIM 614516
CCDS CCDS48039 CCDS6918
HPRD 16835
IMGT
EMBL AK290713 AK293627 AL592211 AY189675 BC009493 BC033686 BC040152 CH471090 Y17455
GenPept AAH09493 AAH33686 AAH40152 AAO34712 BAF83402 BAG57084 CAB44348 CAI12369 CAQ10247 EAW87868 EAW87872
RNA Seq Atlas 57171

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca