Version 5.4
Homo sapiens Gene: CAPN11
Summary
InnateDB Gene IDBG-89052.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN11
Gene Name calpain 11
Synonyms calpain11
Species Homo sapiens
Ensembl Gene ENSG00000137225
Encoded Proteins
IDBP-232221
calpain 11
IDBP-584924
calpain 11
IDBP-593255
calpain 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:44158811-44184402
Strand Forward strand
Band p21.1
Transcripts
ENST00000398776 ENSP00000381758
ENST00000532171 ENSP00000432420
ENST00000526118 ENSP00000431963
ENST00000524554
ENST00000533604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058626
View Gene Order
ENSBTAG00000021066
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.225953
RefSeq NM_007058 XM_006714984 XM_006714986 XM_006714987
HUGO
OMIM
CCDS CCDS47436
HPRD 05315
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca