Version 5.4
Homo sapiens Gene: TARDBP
Summary
InnateDB Gene IDBG-89123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TARDBP
Gene Name TAR DNA binding protein
Synonyms ALS10; TDP-43
Species Homo sapiens
Ensembl Gene ENSG00000120948
Encoded Proteins
IDBP-89125
TAR DNA binding protein
IDBP-89131
TAR DNA binding protein
IDBP-368347
TAR DNA binding protein
IDBP-721532
IDBP-722530
IDBP-721732
IDBP-601571
TAR DNA binding protein
IDBP-722440
IDBP-722004
IDBP-812673
TAR DNA binding protein
IDBP-812677
TAR DNA binding protein
IDBP-812678
TAR DNA binding protein
IDBP-812679
TAR DNA binding protein
IDBP-812680
TAR DNA binding protein
IDBP-812682
TAR DNA binding protein
IDBP-812683
TAR DNA binding protein
IDBP-812685
TAR DNA binding protein
IDBP-812686
TAR DNA binding protein
IDBP-812687
TAR DNA binding protein
IDBP-812688
TAR DNA binding protein
IDBP-812690
TAR DNA binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:11012344-11026420
Strand Forward strand
Band p36.22
Transcripts
ENST00000240185 ENSP00000240185
ENST00000315091 ENSP00000313129
ENST00000439080 ENSP00000404666
ENST00000473118 ENSP00000465240
ENST00000476201 ENSP00000466842
ENST00000472476 ENSP00000465080
ENST00000473869 ENSP00000432132
ENST00000477447 ENSP00000465888
ENST00000496840 ENSP00000467020
ENST00000480464
ENST00000613864
ENST00000621715 ENSP00000480690
ENST00000621790 ENSP00000482191
ENST00000616545 ENSP00000484722
ENST00000622057 ENSP00000481206
ENST00000617172 ENSP00000479219
ENST00000618606
ENST00000611963 ENSP00000481330
ENST00000620632 ENSP00000480771
ENST00000619555 ENSP00000479978
ENST00000610369 ENSP00000482559
ENST00000614494 ENSP00000482754
ENST00000620505 ENSP00000479758
ENST00000621573 ENSP00000477852
ENST00000611008
ENST00000613177
ENST00000617757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 311 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 311 [view]
Protein-Protein 311 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006397 mRNA processing
GO:0008219 cell death
GO:0008380 RNA splicing
GO:0043922 negative regulation by host of viral transcription
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070935 3'-UTR-mediated mRNA stabilization
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041459
View Gene Order
ENSBTAG00000003697
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 23435
UniGene
RefSeq NM_007375
HUGO HGNC:11571
OMIM 605078
CCDS CCDS122
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 23435

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca