InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAGEA2B

Summary

InnateDB Gene

IDBG-89149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAGEA2B

Gene Name

melanoma antigen family A, 2B

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000183305

Encoded Proteins

IDBP-89155

melanoma antigen family A, 2B

IDBP-89157

melanoma antigen family A, 2B

IDBP-294471

melanoma antigen family A, 2B

IDBP-382540

melanoma antigen family A, 2B

IDBP-382542

melanoma antigen family A, 2B

IDBP-382544

melanoma antigen family A, 2B

IDBP-382545

melanoma antigen family A, 2B

IDBP-382548

melanoma antigen family A, 2B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. [provided by RefSeq, Jul 2008] This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:152714586-152718607

Strand

Forward strand

Band

q28

Transcripts

ENST00000331220	ENSP00000333487
ENST00000370293	ENSP00000359316
ENST00000409560	ENSP00000386463
ENST00000423993	ENSP00000395386
ENST00000447530	ENSP00000389223
ENST00000458057	ENSP00000389999
ENST00000422085	ENSP00000397216
ENST00000453150	ENSP00000413384
ENST00000492402
ENST00000497578
ENST00000467743

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042826	histone deacetylase binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0033234	negative regulation of protein sumoylation
GO:0044257	cellular protein catabolic process
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0072331	signal transduction by p53 class mediator
GO:0090398	cellular senescence
GO:1901984	negative regulation of protein acetylation

Cellular Component

GO:0005634	nucleus
GO:0016605	PML body

Orthologs

No orthologs found for this gene

Cross-References

SwissProt

P43356

TrEMBL

A0A024RC17 B9A060 E7ENJ0 E7EP80 E7EQY6 E7ER35 E9PC03

UniProt Splice Variant

Entrez Gene

4101

UniGene

Hs.713061 Hs.736992

RefSeq

NM_153488 XM_005277839

HUGO

HGNC:19340

OMIM

300173 300549

CCDS

CCDS76046

HPRD

14347

IMGT

EMBL

AF002997 AK290443 BC108720 BC112158 BC112160 CH471169 L18920 U82671

GenPept

AAA17729 AAI08721 AAI12159 AAI12161 BAF83132 EAW99429 EAW99430 EAW99431

RNA Seq Atlas

266740 4101