Version 5.4
Homo sapiens Gene: SRM
Summary
InnateDB Gene IDBG-89203.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRM
Gene Name spermidine synthase
Synonyms PAPT; SPDSY; SPS1; SRML1
Species Homo sapiens
Ensembl Gene ENSG00000116649
Encoded Proteins
IDBP-89205
spermidine synthase
IDBP-722512
IDBP-721688
IDBP-722261
IDBP-721810
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:11054584-11060024
Strand Reverse strand
Band p36.22
Transcripts
ENST00000376957 ENSP00000366156
ENST00000475189
ENST00000490101 ENSP00000465966
ENST00000459997 ENSP00000465687
ENST00000465788 ENSP00000467669
ENST00000487300 ENSP00000468760
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0008152 metabolic process
GO:0008295 spermidine biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006442
View Gene Order
ENSBTAG00000005304
Not yet available
Pathways
NETPATH
REACTOME
REACT_14820
Metabolism of polyamines pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00480
Glutathione metabolism pathway
hsa00410
beta-Alanine metabolism pathway
hsa00270
Cysteine and methionine metabolism pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003132
HUGO
OMIM
CCDS CCDS125
HPRD 01692
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca