Version 5.4
Homo sapiens Gene: EXOSC10
Summary
InnateDB Gene IDBG-89211.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOSC10
Gene Name exosome component 10
Synonyms p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p
Species Homo sapiens
Ensembl Gene ENSG00000171824
Encoded Proteins
IDBP-89213
exosome component 10
IDBP-89215
exosome component 10
IDBP-722147
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:11066618-11099881
Strand Reverse strand
Band p36.22
Transcripts
ENST00000376936 ENSP00000366135
ENST00000304457 ENSP00000307307
ENST00000474216
ENST00000490565
ENST00000469634
ENST00000478271
ENST00000470611
ENST00000498576
ENST00000472078
ENST00000485606
ENST00000460196 ENSP00000465008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
Experimentally validated
Total 82 [view]
Protein-Protein 82 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003824 catalytic activity
GO:0004532 exoribonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000460 maturation of 5.8S rRNA
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006396 RNA processing
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0044237 cellular metabolic process
GO:0071028 nuclear mRNA surveillance
GO:0071034 CUT catabolic process
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071044 histone mRNA catabolic process
GO:0071048 nuclear retention of unspliced pre-mRNA at the site of transcription
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0035327 transcriptionally active chromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017264
View Gene Order
ENSBTAG00000002590
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.606076
RefSeq NM_001001998 NM_002685 XM_005263475 XM_005263476
HUGO
OMIM
CCDS CCDS126 CCDS30584
HPRD 16180
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca