Version 5.4
Homo sapiens Gene: MXI1
Summary
InnateDB Gene IDBG-89236.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MXI1
Gene Name MAX interactor 1, dimerization protein
Synonyms bHLHc11; MAD2; MXD2; MXI
Species Homo sapiens
Ensembl Gene ENSG00000119950
Encoded Proteins
IDBP-89238
MAX interactor 1
IDBP-89244
MAX interactor 1
IDBP-89246
MAX interactor 1
IDBP-89252
MAX interactor 1
IDBP-244231
MAX interactor 1
IDBP-385323
MAX interactor 1
IDBP-385331
MAX interactor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:110207605-110287365
Strand Forward strand
Band q25.2
Transcripts
ENST00000332674 ENSP00000331152
ENST00000239007 ENSP00000239007
ENST00000361248 ENSP00000354606
ENST00000369612 ENSP00000358625
ENST00000393134 ENSP00000376842
ENST00000453116 ENSP00000398981
ENST00000442296 ENSP00000407711
ENST00000460667
ENST00000484030
ENST00000485566
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0042994 cytoplasmic sequestering of transcription factor
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025025
View Gene Order
ENSBTAG00000017263
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.501023 Hs.602078 Hs.743585
RefSeq NM_001008541 NM_005962 NM_130439
HUGO
OMIM
CCDS CCDS31284 CCDS7563 CCDS7564
HPRD 02486
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca