InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HSP90AB1

Summary

InnateDB Gene

IDBG-89293.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSP90AB1

Gene Name

heat shock protein 90kDa alpha (cytosolic), class B member 1

Synonyms

D6S182; HSP84; HSP90B; HSPC2; HSPCB

Species

Homo sapiens

Ensembl Gene

ENSG00000096384

Encoded Proteins

IDBP-89295

heat shock protein 90kDa alpha (cytosolic), class B member 1

IDBP-89297

heat shock protein 90kDa alpha (cytosolic), class B member 1

IDBP-89307

heat shock protein 90kDa alpha (cytosolic), class B member 1

IDBP-808192

heat shock protein 90kDa alpha (cytosolic), class B member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:44246166-44253888

Strand

Forward strand

Band

p21.1

Transcripts

ENST00000353801	ENSP00000325875
ENST00000371646	ENSP00000360709
ENST00000371554	ENSP00000360609
ENST00000620073	ENSP00000481908

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 301 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	301 [view]
Protein-Protein	300 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002134	UTP binding
GO:0002135	CTP binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0017098	sulfonylurea receptor binding
GO:0019901	protein kinase binding
GO:0023026	MHC class II protein complex binding
GO:0030235	nitric-oxide synthase regulator activity
GO:0030911	TPR domain binding
GO:0032564	dATP binding
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0001890	placenta development
GO:0006457	protein folding
GO:0006950	response to stress
GO:0006986	response to unfolded protein
GO:0007411	axon guidance
GO:0009651	response to salt stress
GO:0032092	positive regulation of protein binding
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045793	positive regulation of cell size
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0071353	cellular response to interleukin-4
GO:0071407	cellular response to organic cyclic compound
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0008180	COP9 signalosome
GO:0009986	cell surface
GO:0016020	membrane
GO:0016234	inclusion body
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000023944

View Gene Order

Pathways

NETPATH

NetPath_9

TNFalpha pathway

NetPath_11

TCR pathway

REACTOME

REACT_160086

Regulation of actin dynamics for phagocytic cup formation pathway

REACT_75808

The NLRP3 inflammasome pathway

REACT_75900

Inflammasomes pathway

REACT_19236

Sema3A PAK dependent Axon repulsion pathway

REACT_120956

Cellular responses to stress pathway

REACT_111045

Developmental Biology pathway

REACT_19271

Semaphorin interactions pathway

REACT_6802

Innate Immune System pathway

REACT_200624

Attenuation phase pathway

REACT_18266

Axon guidance pathway

REACT_75913

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway

REACT_6900

Immune System pathway

REACT_200775

HSF1-dependent transactivation pathway

REACT_200819

Cellular response to heat stress pathway

REACT_160123

Fcgamma receptor (FCGR) dependent phagocytosis pathway

REACT_200744

HSF1 activation pathway

KEGG

hsa04612

Antigen processing and presentation pathway

hsa05215

Prostate cancer pathway

hsa05200

Pathways in cancer pathway

hsa04914

Progesterone-mediated oocyte maturation pathway

hsa04621

NOD-like receptor signaling pathway pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

vegfr1_2_pathway

Signaling events mediated by VEGFR1 and VEGFR2

Cross-References

SwissProt

P08238

TrEMBL

A0A024RD80 A8K3W9

UniProt Splice Variant

Entrez Gene

3326

UniGene

Hs.509736 Hs.608245

RefSeq

NM_001271971 NM_001271972 NM_007355 NM_001271969 NM_001271970 XM_005249075

HUGO

HGNC:5258

OMIM

140572

CCDS

CCDS4909

HPRD

06763

IMGT

EMBL

AF275719 AH007358 AK290734 AK312255 AL136543 AL139392 AY359878 BC004928 BC009206 BC012807 BC014485 BC016753 BC068474 CH471081 DQ314872 J04988 M16660

GenPept

AAA36025 AAA36026 AAD14062 AAF82792 AAH04928 AAH09206 AAH12807 AAH14485 AAH16753 AAH68474 AAQ63401 ABC40731 BAF83423 BAG35187 CAB66478 CAI20095 EAX04257 EAX04258 EAX04260

RNA Seq Atlas

3326