InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXO6

Summary

InnateDB Gene

IDBG-89462.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO6

Gene Name

F-box protein 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000116663

Encoded Proteins

IDBP-89464

F-box protein 6

IDBP-368732

F-box protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:11664124-11674354

Strand

Forward strand

Band

p36.22

Transcripts

ENST00000376753	ENSP00000365944
ENST00000449067	ENSP00000388781
ENST00000474239

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 609 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	609 [view]
Protein-Protein	609 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006281	DNA repair
GO:0006508	proteolysis
GO:0006516	glycoprotein catabolic process
GO:0006986	response to unfolded protein
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0019005	SCF ubiquitin ligase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000055401

View Gene Order

ENSBTAG00000014777

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_16907

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_16952

Protein folding pathway

REACT_17004

Chaperonin-mediated protein folding pathway

REACT_17015

Metabolism of proteins pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.464419

RefSeq

NM_018438 XM_005263448 XM_005263449 XM_005263451 XM_006710571

HUGO

OMIM

CCDS

CCDS133

HPRD

07291

IMGT

EMBL

GenPept

RNA Seq Atlas