InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDCD4

Summary

InnateDB Gene

IDBG-89535.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD4

Gene Name

programmed cell death 4 (neoplastic transformation inhibitor)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000150593

Encoded Proteins

IDBP-89537

programmed cell death 4 (neoplastic transformation inhibitor)

IDBP-244284

programmed cell death 4 (neoplastic transformation inhibitor)

IDBP-385397

programmed cell death 4 (neoplastic transformation inhibitor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:110871795-110900006

Strand

Forward strand

Band

q25.2

Transcripts

ENST00000280154	ENSP00000280154
ENST00000393104	ENSP00000376816
ENST00000444997	ENSP00000394668
ENST00000467574
ENST00000483670
ENST00000492932
ENST00000481353
ENST00000462577
ENST00000489049
ENST00000483595
ENST00000498367

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007569	cell aging
GO:0043508	negative regulation of JUN kinase activity
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024975

View Gene Order

ENSBTAG00000019434

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

mtor_4pathway

mTOR signaling pathway

Cross-References

SwissProt

Q53EL6

TrEMBL

UniProt Splice Variant

Entrez Gene

27250

UniGene

Hs.711490 Hs.733516

RefSeq

NM_001199492 NM_014456 XM_006717767 NM_145341

HUGO

HGNC:8763

OMIM

608610

CCDS

CCDS7567 CCDS44478

HPRD

10549

IMGT

EMBL

AK223623 AK315295 AL136368 AL158163 BC015036 BC026104 BC031049 U83908 U96628

GenPept

AAB42218 AAB67706 AAH15036 AAH26104 AAH31049 BAD97343 BAG37701 CAH72815 CAI40095

RNA Seq Atlas

100616113 27250