InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPAM

Summary

InnateDB Gene

IDBG-89712.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPAM

Gene Name

glycerol-3-phosphate acyltransferase, mitochondrial

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000119927

Encoded Proteins

IDBP-89716

glycerol-3-phosphate acyltransferase, mitochondrial

IDBP-89718

glycerol-3-phosphate acyltransferase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:112149864-112215377

Strand

Reverse strand

Band

q25.2

Transcripts

ENST00000348367	ENSP00000265276
ENST00000369425	ENSP00000358433
ENST00000480130
ENST00000498541

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004366	glycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0006641	triglyceride metabolic process
GO:0006644	phospholipid metabolic process
GO:0006650	glycerophospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0009749	response to glucose
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0040018	positive regulation of multicellular organism growth
GO:0042104	positive regulation of activated T cell proliferation
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050707	regulation of cytokine secretion
GO:0051607	defense response to virus
GO:0055089	fatty acid homeostasis
GO:0055091	phospholipid homeostasis
GO:0070236	negative regulation of activation-induced cell death of T cells
GO:0070970	interleukin-2 secretion

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane