Version 5.4
Homo sapiens Gene: RCAN2
Summary
InnateDB Gene IDBG-89839.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RCAN2
Gene Name regulator of calcineurin 2
Synonyms CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4
Species Homo sapiens
Ensembl Gene ENSG00000172348
Encoded Proteins
IDBP-89841
regulator of calcineurin 2
IDBP-89843
regulator of calcineurin 2
IDBP-89847
regulator of calcineurin 2
IDBP-294548
regulator of calcineurin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:46220736-46491972
Strand Reverse strand
Band p12.3
Transcripts
ENST00000306764 ENSP00000305223
ENST00000371374 ENSP00000360425
ENST00000330430 ENSP00000329454
ENST00000405162 ENSP00000384317
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
Biological Process
GO:0006979 response to oxidative stress
GO:0007614 short-term memory
GO:0019722 calcium-mediated signaling
GO:0031987 locomotion involved in locomotory behavior
GO:0033173 calcineurin-NFAT signaling cascade
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039601
View Gene Order
ENSBTAG00000009302
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt Q14206
TrEMBL
UniProt Splice Variant
Entrez Gene 10231
UniGene Hs.440168
RefSeq NM_001251973 NM_001251974 NM_005822 XM_006714948
HUGO HGNC:3041
OMIM 604876
CCDS CCDS59023 CCDS43469
HPRD 05342
IMGT
EMBL AK090990 AL359633 AL390741 AY034085 AY034086 CH471081 D83407
GenPept AAK59805 AAK59806 BAA11911 BAG52258 CAH73259 CAH73260 CAI16754 EAX04294
RNA Seq Atlas 10231

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca