InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCD1

Summary

InnateDB Gene

IDBG-89886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCD1

Gene Name

ATP-binding cassette, sub-family D (ALD), member 1

Synonyms

ABC42; ALD; ALDP; AMN

Species

Homo sapiens

Ensembl Gene

ENSG00000101986

Encoded Proteins

IDBP-89888

ATP-binding cassette, sub-family D (ALD), member 1

IDBP-89890

ATP-binding cassette, sub-family D (ALD), member 1

IDBP-382979

ATP-binding cassette, sub-family D (ALD), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:153724868-153744762

Strand

Forward strand

Band

q28

Transcripts

ENST00000218104	ENSP00000218104
ENST00000370129	ENSP00000359147
ENST00000443684	ENSP00000413695

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005325	peroxisomal fatty-acyl-CoA transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006810	transport
GO:0007031	peroxisome organization
GO:0015910	peroxisomal long-chain fatty acid import
GO:0015919	peroxisomal membrane transport
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase
GO:0033559	unsaturated fatty acid metabolic process
GO:0036109	alpha-linolenic acid metabolic process
GO:0042758	long-chain fatty acid catabolic process
GO:0042760	very long-chain fatty acid catabolic process
GO:0043651	linoleic acid metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005779	integral component of peroxisomal membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm