Version 5.4
Homo sapiens Gene: IDH3G
Summary
InnateDB Gene IDBG-89977.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDH3G
Gene Name isocitrate dehydrogenase 3 (NAD+) gamma
Synonyms H-IDHG
Species Homo sapiens
Ensembl Gene ENSG00000067829
Encoded Proteins
IDBP-89979
isocitrate dehydrogenase 3 (NAD+) gamma
IDBP-89981
isocitrate dehydrogenase 3 (NAD+) gamma
IDBP-89983
isocitrate dehydrogenase 3 (NAD+) gamma
IDBP-383052
isocitrate dehydrogenase 3 (NAD+) gamma
IDBP-383054
isocitrate dehydrogenase 3 (NAD+) gamma
IDBP-383058
isocitrate dehydrogenase 3 (NAD+) gamma
IDBP-383059
isocitrate dehydrogenase 3 (NAD+) gamma
IDBP-812935
isocitrate dehydrogenase 3 (NAD+) gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:153785766-153794523
Strand Reverse strand
Band q28
Transcripts
ENST00000217901 ENSP00000217901
ENST00000370093 ENSP00000359111
ENST00000370092 ENSP00000359110
ENST00000427365 ENSP00000408529
ENST00000454076 ENSP00000400115
ENST00000444450 ENSP00000401862
ENST00000444338 ENSP00000402747
ENST00000497043
ENST00000495356
ENST00000461215
ENST00000491235
ENST00000619865 ENSP00000482665
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0005524 ATP binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002010
View Gene Order
ENSBTAG00000001059
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_17015
Metabolism of proteins pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.410197
RefSeq NM_004135 NM_174869
HUGO
OMIM
CCDS CCDS14730 CCDS44019
HPRD 02100
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca