Version 5.4
Homo sapiens Gene: GFI1B
Summary
InnateDB Gene IDBG-90485.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFI1B
Gene Name growth factor independent 1B transcription repressor
Synonyms BDPLT17
Species Homo sapiens
Ensembl Gene ENSG00000165702
Encoded Proteins
IDBP-90487
growth factor independent 1B transcription repressor
IDBP-90491
growth factor independent 1B transcription repressor
IDBP-90493
growth factor independent 1B transcription repressor
IDBP-603143
growth factor independent 1B transcription repressor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:132945551-132991696
Strand Forward strand
Band q34.13
Transcripts
ENST00000339463 ENSP00000344782
ENST00000372122 ENSP00000361195
ENST00000372123 ENSP00000361196
ENST00000534944 ENSP00000446134
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 80 [view]
Protein-Protein 80 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0016568 chromatin modification
GO:0030854 positive regulation of granulocyte differentiation
GO:0045646 regulation of erythrocyte differentiation
GO:0051572 negative regulation of histone H3-K4 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026815
View Gene Order
ENSBTAG00000012772
Not yet available
Cross-References
SwissProt Q5VTD9
TrEMBL A0A024R8F3
UniProt Splice Variant
Entrez Gene 8328
UniGene Hs.553160 Hs.736976
RefSeq NM_001135031 NM_004188
HUGO HGNC:4238
OMIM 604383
CCDS CCDS48049 CCDS6957
HPRD
IMGT
EMBL AF081946 AL593851 AY428733 BC035626 BC043371 CH471090 CR536546
GenPept AAD08672 AAH43371 AAR06639 CAG38783 CAH73618 CAH73619 EAW88023 EAW88024 EAW88025
RNA Seq Atlas 8328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca