InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MCM3

Summary

InnateDB Gene

IDBG-90549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM3

Gene Name

minichromosome maintenance complex component 3

Synonyms

HCC5; P1-MCM3; P1.h; RLFB

Species

Homo sapiens

Ensembl Gene

ENSG00000112118

Encoded Proteins

IDBP-90551

minichromosome maintenance complex component 3

IDBP-381534

minichromosome maintenance complex component 3

IDBP-381555

minichromosome maintenance complex component 3

IDBP-718777

IDBP-719064

IDBP-808259

minichromosome maintenance complex component 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:52264009-52284881

Strand

Reverse strand

Band

p12.2

Transcripts

ENST00000229854	ENSP00000229854
ENST00000419835	ENSP00000388647
ENST00000421471	ENSP00000407651
ENST00000476448
ENST00000596983	ENSP00000470057
ENST00000596288	ENSP00000472940
ENST00000616552	ENSP00000480987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 130 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	130 [view]
Protein-Protein	122 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005658	alpha DNA polymerase:primase complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0042555	MCM complex
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm