InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NAA10

Summary

InnateDB Gene

IDBG-90615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAA10

Gene Name

N(alpha)-acetyltransferase 10, NatA catalytic subunit

Synonyms

ARD1; ARD1A; ARD1P; DXS707; MCOPS1; NATD; TE2

Species

Homo sapiens

Ensembl Gene

ENSG00000102030

Encoded Proteins

IDBP-90617

N(alpha)-acetyltransferase 10, NatA catalytic subunit

IDBP-90619

N(alpha)-acetyltransferase 10, NatA catalytic subunit

IDBP-90621

N(alpha)-acetyltransferase 10, NatA catalytic subunit

IDBP-243061

N(alpha)-acetyltransferase 10, NatA catalytic subunit

IDBP-383212

N(alpha)-acetyltransferase 10, NatA catalytic subunit

IDBP-484870

N(alpha)-acetyltransferase 10, NatA catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:153929242-153935223

Strand

Reverse strand

Band

q28

Transcripts

ENST00000370015	ENSP00000359032
ENST00000370011	ENSP00000359028
ENST00000370009	ENSP00000359026
ENST00000393712	ENSP00000377315
ENST00000393710
ENST00000432089	ENSP00000413668
ENST00000464845	ENSP00000417763
ENST00000482485
ENST00000466877
ENST00000484950
ENST00000460996
ENST00000467451
ENST00000477750
ENST00000477882
ENST00000478177
ENST00000488481

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	32 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004596	peptide alpha-N-acetyltransferase activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0016407	acetyltransferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0043022	ribosome binding

Biological Process

GO:0006323	DNA packaging
GO:0006474	N-terminal protein amino acid acetylation
GO:0006475	internal protein amino acid acetylation
GO:0008152	metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031415	NatA complex

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000031388

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

hif1apathway

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Cross-References

SwissProt

P41227

TrEMBL

UniProt Splice Variant

Entrez Gene

8260

UniGene

RefSeq

NM_001256120 NM_003491 NM_001256119

HUGO

HGNC:18704

OMIM

300013

CCDS

CCDS14737 CCDS59179

HPRD

02056

IMGT

EMBL

BC000308 BC019312 CH471172 U52112 X77588

GenPept

AAH00308 AAH19312 CAA54691 EAW72774

RNA Seq Atlas

8260