Version 5.4
Homo sapiens Gene: PNLIP
Summary
InnateDB Gene IDBG-90643.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PNLIP
Gene Name pancreatic lipase
Synonyms PL; PNLIPD; PTL
Species Homo sapiens
Ensembl Gene ENSG00000175535
Encoded Proteins
IDBP-90645
pancreatic lipase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:116545931-116567855
Strand Forward strand
Band q25.3
Transcripts
ENST00000369221 ENSP00000358223
ENST00000470562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004806 triglyceride lipase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0006629 lipid metabolic process
GO:0007603 phototransduction, visible light
GO:0016042 lipid catabolic process
GO:0030299 intestinal cholesterol absorption
GO:0044241 lipid digestion
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046008
View Gene Order
ENSBTAG00000032237
Not yet available
Pathways
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_9518
Digestion of dietary lipid pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
KEGG
hsa00561
Glycerolipid metabolism pathway
hsa04975
Fat digestion and absorption pathway
hsa04972
Pancreatic secretion pathway
INOH
PID NCI
Cross-References
SwissProt P16233
TrEMBL
UniProt Splice Variant
Entrez Gene 5406
UniGene Hs.501135
RefSeq NM_000936
HUGO HGNC:9155
OMIM 246600
CCDS CCDS7594
HPRD
IMGT
EMBL AK313941 AL731653 BC014309 CH471066 J05125 L11242 L24502 L24522 L24523 L24525 L24526 L24527 L24528 L24529 M93285
GenPept AAA36740 AAA60129 AAA99053 AAH14309 BAG36659 CAH72667 EAW49451
RNA Seq Atlas 5406

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca