Version 5.4
Homo sapiens Gene: TINAG
Summary
InnateDB Gene IDBG-91109.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TINAG
Gene Name tubulointerstitial nephritis antigen
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137251
Encoded Proteins
IDBP-91111
tubulointerstitial nephritis antigen
IDBP-91115
tubulointerstitial nephritis antigen
IDBP-91121
tubulointerstitial nephritis antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:54307859-54390152
Strand Forward strand
Band p12.1
Transcripts
ENST00000370869 ENSP00000359906
ENST00000259782 ENSP00000259782
ENST00000370864 ENSP00000359901
ENST00000486436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004197 cysteine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0008234 cysteine-type peptidase activity
GO:0030247 polysaccharide binding
Biological Process
GO:0006508 proteolysis
GO:0006898 receptor-mediated endocytosis
GO:0006955 immune response
GO:0007155 cell adhesion
Cellular Component
GO:0005604 basement membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032357
View Gene Order
ENSBTAG00000012652
Not yet available
Cross-References
SwissProt
TrEMBL Q5T466
UniProt Splice Variant
Entrez Gene 27283
UniGene
RefSeq NM_014464 XM_006715061 XM_006715062 XM_006715064
HUGO HGNC:14599
OMIM 606749
CCDS CCDS4955
HPRD 09483
IMGT
EMBL AL359380 AL589946
GenPept
RNA Seq Atlas 27283

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca