Version 5.4
Homo sapiens Gene: TIAL1
Summary
InnateDB Gene IDBG-91185.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIAL1
Gene Name TIA1 cytotoxic granule-associated RNA binding protein-like 1
Synonyms TCBP; TIAR
Species Homo sapiens
Ensembl Gene ENSG00000151923
Encoded Proteins
IDBP-91187
TIA1 cytotoxic granule-associated RNA binding protein-like 1
IDBP-91199
TIA1 cytotoxic granule-associated RNA binding protein-like 1
IDBP-386072
TIA1 cytotoxic granule-associated RNA binding protein-like 1
IDBP-386075
TIA1 cytotoxic granule-associated RNA binding protein-like 1
IDBP-475480
TIA1 cytotoxic granule-associated RNA binding protein-like 1
IDBP-813734
TIA1 cytotoxic granule-associated RNA binding protein-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:119571802-119597029
Strand Reverse strand
Band q26.11
Transcripts
ENST00000369093 ENSP00000358089
ENST00000369087
ENST00000369086 ENSP00000358082
ENST00000436547 ENSP00000394902
ENST00000412524 ENSP00000403573
ENST00000463089
ENST00000489822
ENST00000497671 ENSP00000431009
ENST00000470781
ENST00000495821
ENST00000470635
ENST00000462373
ENST00000479729 ENSP00000480825
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 15 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0017091 AU-rich element binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0007281 germ cell development
GO:0008284 positive regulation of cell proliferation
GO:0017145 stem cell division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0010494 cytoplasmic stress granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030846
View Gene Order
ENSBTAG00000004080
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.501203
RefSeq NM_001033925 NM_003252
HUGO
OMIM
CCDS CCDS31295 CCDS7613
HPRD 04563
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca