InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BMP5

Summary

InnateDB Gene

IDBG-91207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMP5

Gene Name

bone morphogenetic protein 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000112175

Encoded Proteins

IDBP-91209

bone morphogenetic protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:55753645-55875564

Strand

Reverse strand

Band

p12.1

Transcripts

ENST00000370830

ENSP00000359866

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0070700	BMP receptor binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0003323	type B pancreatic cell development
GO:0007389	pattern specification process
GO:0008285	negative regulation of cell proliferation
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894	negative regulation of steroid biosynthetic process
GO:0030539	male genitalia development
GO:0032348	negative regulation of aldosterone biosynthetic process
GO:0040007	growth
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051216	cartilage development
GO:0071676	negative regulation of mononuclear cell migration
GO:1900006	positive regulation of dendrite development
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000065	negative regulation of cortisol biosynthetic process
GO:2000105	positive regulation of DNA-dependent DNA replication

Cellular Component

GO:0005575	cellular_component
GO:0005615	extracellular space
GO:0031988	membrane-bounded vesicle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032179

View Gene Order

ENSBTAG00000012870

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04350

TGF-beta signaling pathway pathway

INOH

INOH website

GPCR signaling pathway

INOH website

TGF-beta signaling pathway

INOH website

BMP2 signaling pathway

PID NCI

Cross-References

SwissProt

P22003

TrEMBL

M9VUD0

UniProt Splice Variant

Entrez Gene

653

UniGene

Hs.296648 Hs.596689 Hs.656729

RefSeq

NM_021073 XM_005249304

HUGO

HGNC:1072

OMIM

112265

CCDS

CCDS4958

HPRD

IMGT

EMBL

AL133386 AL137178 BC027958 CH471081 KC485577 M60314

GenPept

AAA36736 AAH27958 AGJ83825 CAB81657 CAC12765 EAX04447

RNA Seq Atlas

653