InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EMD

Summary

InnateDB Gene

IDBG-91213.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EMD

Gene Name

emerin

Synonyms

EDMD; LEMD5; STA

Species

Homo sapiens

Ensembl Gene

ENSG00000102119

Encoded Proteins

IDBP-91215

emerin

IDBP-91217

emerin

IDBP-383531

emerin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:154379197-154381523

Strand

Forward strand

Band

q28

Transcripts

ENST00000369842	ENSP00000358857
ENST00000369835	ENSP00000358850
ENST00000428228	ENSP00000401081
ENST00000486738
ENST00000485261
ENST00000494443
ENST00000468294
ENST00000492448
ENST00000471965

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 148 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	148 [view]
Protein-Protein	146 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006936	muscle contraction
GO:0007077	mitotic nuclear envelope disassembly
GO:0007084	mitotic nuclear envelope reassembly
GO:0007517	muscle organ development
GO:0035414	negative regulation of catenin import into nucleus
GO:0035914	skeletal muscle cell differentiation
GO:0046827	positive regulation of protein export from nucleus
GO:0048147	negative regulation of fibroblast proliferation
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005640	nuclear outer membrane
GO:0005783	endoplasmic reticulum
GO:0005874	microtubule
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane