Version 5.4
Homo sapiens Gene: BAG3
Summary
InnateDB Gene IDBG-91218.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAG3
Gene Name BCL2-associated athanogene 3
Synonyms BAG-3; BIS; CAIR-1; MFM6
Species Homo sapiens
Ensembl Gene ENSG00000151929
Encoded Proteins
IDBP-91220
BCL2-associated athanogene 3
IDBP-386077
BCL2-associated athanogene 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:119651370-119677819
Strand Forward strand
Band q26.11
Transcripts
ENST00000369085 ENSP00000358081
ENST00000450186 ENSP00000410036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 437 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 437 [view]
Protein-Protein 437 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0007420 brain development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0021510 spinal cord development
GO:0043066 negative regulation of apoptotic process
GO:0050821 protein stabilization
GO:0071260 cellular response to mechanical stimulus
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030018 Z disc
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030847
View Gene Order
ENSBTAG00000013641
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523309 Hs.726135
RefSeq NM_004281 XM_005270287
HUGO
OMIM
CCDS CCDS7615
HPRD 04860
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca