Version 5.4
Homo sapiens Gene: CLCNKA
Summary
InnateDB Gene IDBG-91284.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLCNKA
Gene Name chloride channel, voltage-sensitive Ka
Synonyms ClC-K1; CLCK1; hClC-Ka
Species Homo sapiens
Ensembl Gene ENSG00000186510
Encoded Proteins
IDBP-91286
chloride channel Ka
IDBP-91288
chloride channel Ka
IDBP-371515
chloride channel Ka
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:16018875-16034050
Strand Forward strand
Band p36.13
Transcripts
ENST00000375692 ENSP00000364844
ENST00000331433 ENSP00000332771
ENST00000439316 ENSP00000414445
ENST00000477360
ENST00000464764
ENST00000495784
ENST00000491433
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0030554 adenyl nucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0006810 transport
GO:0006821 chloride transport
GO:0007588 excretion
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000033770
View Gene Order
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591533 Hs.736811
RefSeq NM_001042704 NM_001257139 NM_004070 XM_006710071
HUGO
OMIM
CCDS CCDS167 CCDS41269 CCDS57973
HPRD 03608
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca