InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EPHA2

Summary

InnateDB Gene

IDBG-91407.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA2

Gene Name

EPH receptor A2

Synonyms

ARCC2; CTPA; CTPP1; CTRCT6; ECK

Species

Homo sapiens

Ensembl Gene

ENSG00000142627

Encoded Proteins

IDBP-91411

EPH receptor A2

IDBP-809789

EPH receptor A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:16124337-16156087

Strand

Reverse strand

Band

p36.13

Transcripts

ENST00000358432	ENSP00000351209
ENST00000462805
ENST00000480202
ENST00000461614
ENST00000611929	ENSP00000484980

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	47 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001501	skeletal system development
GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0001649	osteoblast differentiation
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010591	regulation of lamellipodium assembly
GO:0014028	notochord formation
GO:0016032	viral process
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021915	neural tube development
GO:0030182	neuron differentiation
GO:0030216	keratinocyte differentiation
GO:0030316	osteoclast differentiation
GO:0032863	activation of Rac GTPase activity
GO:0033598	mammary gland epithelial cell proliferation
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0036342	post-anal tail morphogenesis
GO:0043491	protein kinase B signaling
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0046849	bone remodeling
GO:0048013	ephrin receptor signaling pathway
GO:0048320	axial mesoderm formation
GO:0048570	notochord morphogenesis
GO:0051898	negative regulation of protein kinase B signaling
GO:0060035	notochord cell development
GO:0060326	cell chemotaxis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0070309	lens fiber cell morphogenesis
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070848	response to growth factor
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0031256	leading edge membrane
GO:0031258	lamellipodium membrane
GO:0032587	ruffle membrane