Version 5.4
Homo sapiens Gene: DBH
Summary
InnateDB Gene IDBG-91512.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DBH
Gene Name dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Synonyms DBM
Species Homo sapiens
Ensembl Gene ENSG00000123454
Encoded Proteins
IDBP-91514
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
IDBP-244403
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:133636360-133659344
Strand Forward strand
Band q34.2
Transcripts
ENST00000263611 ENSP00000263611
ENST00000393056 ENSP00000376776
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0004500 dopamine beta-monooxygenase activity
GO:0005507 copper ion binding
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0001816 cytokine production
GO:0001974 blood vessel remodeling
GO:0001975 response to amphetamine
GO:0002443 leukocyte mediated immunity
GO:0007268 synaptic transmission
GO:0007613 memory
GO:0007626 locomotory behavior
GO:0008306 associative learning
GO:0008542 visual learning
GO:0034641 cellular nitrogen compound metabolic process
GO:0042127 regulation of cell proliferation
GO:0042309 homoiothermy
GO:0042420 dopamine catabolic process
GO:0042421 norepinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
GO:0042593 glucose homeostasis
GO:0042596 fear response
GO:0042711 maternal behavior
GO:0044281 small molecule metabolic process
GO:0045907 positive regulation of vasoconstriction
GO:0048149 behavioral response to ethanol
GO:0048265 response to pain
GO:0050900 leukocyte migration
GO:0055114 oxidation-reduction process
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030658 transport vesicle membrane
GO:0034466 chromaffin granule lumen
GO:0034774 secretory granule lumen
GO:0042584 chromaffin granule membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000889
View Gene Order
ENSBTAG00000004508
Not yet available
Pathways
NETPATH
REACTOME
REACT_15551
Catecholamine biosynthesis pathway
REACT_15513
Amine-derived hormones pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00350
Tyrosine metabolism pathway
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt P09172
TrEMBL
UniProt Splice Variant
Entrez Gene 1621
UniGene Hs.591890
RefSeq NM_000787
HUGO HGNC:2689
OMIM 609312
CCDS CCDS6977
HPRD 01963
IMGT
EMBL AL365494 BC017174 X13255 X13256 Y00096
GenPept AAH17174 CAA31631 CAA31632 CAA68285 CAI13354
RNA Seq Atlas 1621

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca