Version 5.4
Homo sapiens Gene: TACC2
Summary
InnateDB Gene IDBG-91710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TACC2
Gene Name transforming, acidic coiled-coil containing protein 2
Synonyms AZU-1; ECTACC
Species Homo sapiens
Ensembl Gene ENSG00000138162
Encoded Proteins
IDBP-91712
transforming, acidic coiled-coil containing protein 2
IDBP-482828
transforming, acidic coiled-coil containing protein 2
IDBP-91716
transforming, acidic coiled-coil containing protein 2
IDBP-91718
transforming, acidic coiled-coil containing protein 2
IDBP-91720
transforming, acidic coiled-coil containing protein 2
IDBP-91722
transforming, acidic coiled-coil containing protein 2
IDBP-91724
transforming, acidic coiled-coil containing protein 2
IDBP-91728
transforming, acidic coiled-coil containing protein 2
IDBP-91730
transforming, acidic coiled-coil containing protein 2
IDBP-386391
transforming, acidic coiled-coil containing protein 2
IDBP-484101
transforming, acidic coiled-coil containing protein 2
IDBP-480468
transforming, acidic coiled-coil containing protein 2
IDBP-485057
transforming, acidic coiled-coil containing protein 2
IDBP-484791
transforming, acidic coiled-coil containing protein 2
IDBP-484248
transforming, acidic coiled-coil containing protein 2
IDBP-483881
transforming, acidic coiled-coil containing protein 2
IDBP-478171
transforming, acidic coiled-coil containing protein 2
IDBP-478051
transforming, acidic coiled-coil containing protein 2
IDBP-479490
transforming, acidic coiled-coil containing protein 2
IDBP-485027
transforming, acidic coiled-coil containing protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:121989174-122254545
Strand Forward strand
Band q26.13
Transcripts
ENST00000369005 ENSP00000358001
ENST00000369004 ENSP00000422815
ENST00000334433 ENSP00000334280
ENST00000358010 ENSP00000350701
ENST00000369001 ENSP00000357997
ENST00000369000 ENSP00000357996
ENST00000360561 ENSP00000353763
ENST00000260733 ENSP00000260733
ENST00000368999 ENSP00000357995
ENST00000368997
ENST00000453444 ENSP00000395048
ENST00000440764 ENSP00000421702
ENST00000492689
ENST00000513429 ENSP00000425062
ENST00000515273 ENSP00000424467
ENST00000515603 ENSP00000427618
ENST00000498721
ENST00000474014
ENST00000489754
ENST00000491540 ENSP00000423069
ENST00000493951
ENST00000492237
ENST00000514539 ENSP00000420967
ENST00000505639 ENSP00000426303
ENST00000496913 ENSP00000422725
ENST00000508411 ENSP00000425525
ENST00000490979 ENSP00000423764
ENST00000503769
ENST00000465600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0019904 protein domain specific binding
GO:0035257 nuclear hormone receptor binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0008283 cell proliferation
GO:0021987 cerebral cortex development
GO:0022008 neurogenesis
GO:0022027 interkinetic nuclear migration
GO:0030953 astral microtubule organization
GO:0032886 regulation of microtubule-based process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030852
View Gene Order
ENSBTAG00000010786
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10579
UniGene Hs.501252
RefSeq NM_001291876 NM_001291877 NM_001291878 NM_001291879 NM_006997 NM_206860 NM_206861 NM_206862 XM_005269393 XM_005269399 XM_006717548 XM_006717550 XM_006717555 XM_006717556 XM_006717557
HUGO HGNC:11523
OMIM 605302
CCDS CCDS7625 CCDS7626 CCDS7627 CCDS7628
HPRD 05600
IMGT
EMBL
GenPept
RNA Seq Atlas 10579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca