InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WDR5

Summary

InnateDB Gene

IDBG-91736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR5

Gene Name

WD repeat domain 5

Synonyms

BIG-3; CFAP89; SWD3

Species

Homo sapiens

Ensembl Gene

ENSG00000196363

Encoded Proteins

IDBP-91738

WD repeat domain 5

IDBP-809086

WD repeat domain 5

IDBP-809089

WD repeat domain 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:134135365-134159968

Strand

Forward strand

Band

q34.2

Transcripts

ENST00000358625	ENSP00000351446
ENST00000608937	ENSP00000477000
ENST00000608739	ENSP00000477449

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 194 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	194 [view]
Protein-Protein	192 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046972	histone acetyltransferase activity (H4-K16 specific)

Biological Process

GO:0001501	skeletal system development
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043966	histone H3 acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation
GO:0045722	positive regulation of gluconeogenesis
GO:0048511	rhythmic process
GO:0051568	histone H3-K4 methylation

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0035097	histone methyltransferase complex
GO:0048188	Set1C/COMPASS complex
GO:0071339	MLL1 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026917

View Gene Order

ENSBTAG00000047031

Not yet available

Pathways

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_228108

RMTs methylate histone arginines pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

circadianpathway

Circadian rhythm pathway

Cross-References

SwissProt

TrEMBL

V9GYQ5

UniProt Splice Variant

Entrez Gene

11091

UniGene

RefSeq

NM_017588 NM_052821 XM_005272163

HUGO

HGNC:12757

OMIM

609012

CCDS

CCDS6981

HPRD

IMGT

EMBL

BX649632

GenPept

RNA Seq Atlas

11091