InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LMBRD1

Summary

InnateDB Gene

IDBG-91834.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMBRD1

Gene Name

LMBR1 domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000168216

Encoded Proteins

IDBP-91836

LMBR1 domain containing 1

IDBP-91838

LMBR1 domain containing 1

IDBP-595827

LMBR1 domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:69675802-69797111

Strand

Reverse strand

Band

q13

Transcripts

ENST00000370577	ENSP00000359609
ENST00000370570	ENSP00000359602
ENST00000472827	ENSP00000433385

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0031419	cobalamin binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006810	transport
GO:0009235	cobalamin metabolic process
GO:0016032	viral process
GO:0038016	insulin receptor internalization
GO:0044281	small molecule metabolic process
GO:0046325	negative regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0051898	negative regulation of protein kinase B signaling

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045334	clathrin-coated endocytic vesicle