Homo sapiens Gene: GAB3
Summary
InnateDB Gene IDBG-92039.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAB3
Gene Name GRB2-associated binding protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160219
Encoded Proteins
GRB2-associated binding protein 3
GRB2-associated binding protein 3
GRB2-associated binding protein 3
GRB2-associated binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:154675249-154751583
Strand Reverse strand
Band q28
Transcripts
ENST00000369575 ENSP00000358588
ENST00000369568 ENSP00000358581
ENST00000424127 ENSP00000399588
ENST00000454973 ENSP00000412258
ENST00000496390
ENST00000475685
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030225 macrophage differentiation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.496982
RefSeq NM_001081573 NM_001282283 NM_080612 XM_005274648 XM_006724804 XM_006724806
HUGO
OMIM
CCDS CCDS14760 CCDS48198 CCDS65357
HPRD 06571
IMGT
EMBL
GenPept
RNA Seq Atlas